Over the last year, SARS-CoV-2 caused the infection of more than 80 million people and about 1.8 million deaths. Since the emergence of the first cases in China, this virus has been the focal point of the scientific community and represented the main subject of a large number of research publications. It has been observed that the symptomatology is broad, varying from asymptomatic/mild manifestations to more severe stages of illness, in some cases leading to multi-organ failure and death. Although WHO announced PHEIC since January 30, and invited the researchers to quickly find solutions for diagnosis, monitoring, and treatment, there are currently no COVID-19 specific therapeutic drugs or vaccines clinically approved. This led to losses on multiple levels, such as: high number of deaths, health/financial crisis, job loss, school closures, etc. For these reasons, there is an urgent need to properly understand all aspects regarding this virus in order to successfully develop strategies to manage and stop this pandemic. Hence, this paper analysis the current knowledge and provides a comprehensive overview on this novel coronavirus.