Aim: The protective effect of vitamin E (vit E) on cadmium (Cd)
induced oxidative stress was studied in the blood of rats.
Methods: The rats were randomly divided in to three experimental
groups: Control, Cd treated and Cd + vit E treated, each containing
10 animals. The Cd treated and Cd + vit E treated groups were
injected subcutaneously daily with CdCl2 dissolved in isotonic NaCl
in the amount of 2 mL/kg for 20 days, resulting in a dosage of
0.49 mg Cd/kg/d. In addition, Cd + vit E treated group received
intramuscular injection of 150 mg/kg vit E until the end of the
Results: Cd treatment increased significantly malondialdehyde
(MDA) levels and the antioxidant enzyme activities of superoxide
dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase
(CAT) in plasma and erythrocytes compared to the control group.
Cd + vit E treatment, decreased significantly elevated MDA levels
in plasma and erythrocyte and also reduced significantly the
enhanced antioxidant levels. Cd treatment increased significantly
the activity of iron levels in the plasma compared to the control
group. Cd + vit E treatment, decreased the activity of iron levels
in the plasma compared to the Cd treated group. In the control
group, the histology of erythrocytes was normal. In Cd treated
group, there was marked membrane destruction and there were
hemolytic changes in erythrocytes. In Cd + vit E treated group,
these changes were less than Cd treated group.
Conclussion: Our results show that vit E exerts a protective effect
against cadmium toxicity.