Aim: To assess and compare accuracy of the clinical indications and
histopathological diagnoses from hysterectomy specimens in Zaria.
Methods: All hysterectomy specimens received in the department
of Pathology, Ahmadu Bello University Teaching Hospital, Zaria
from January 1995 to December 2005 were analyzed. The specimens
were fixed in formalin, processed in paraffin wax and histology
slides stained with haematoxylin and eosin were studied.
Frequency of clinical indications were compiled and compared with
Results: 317 hysterectomies were analyzed. Of these 288 (90.9%)
were associated with salpingo-oophrectomies. Median age of patients’
was 45 years and mean age was 44.6 years. Parity of the
women ranged from 0-11 with an average of 4.
The clinical indications comprised non-neoplastic- 47 (14.8%) and
neoplastic-226 (71.3%) causes. The commonest benign neoplastic
indication was uterine fibroid 196 (61.8%). Malignant neoplastic indication
included cervical cancer 12 (3.8%) and endometrial cancer
6 (1.9%). Cervical intraepithelial neoplasia (CIN), a preneoplastic
lesion accounted for 44 (13.9%). Histopathological diagnosis of
leiomyoma was made in 218 (68.8%), cervical cancer –20 (6.3%) and
CIN- 49 (15.5%). Incidental pathologies seen included chronic cervicitis
-24, adenomyosis- 13 and cystadenoma – 8. Clinical indications
in 14 (4.4%) patients were at variance with histological diagnosis.
Conclusion: The clinical indication for hysterectomy and histopathological
outcome are comparable in over 90% of cases. The
commonest indication and histological finding in our setting is