Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome and Malignancy
Mehmet Sayarlıoğlu 1 *
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1 Yüzüncü Yıl University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Van, Turkey
* Corresponding Author


Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is a definite subset of the seronegative symmetrical polyarthritis of the aged, characterized by dramatic pitting edema of the hands, male predominance, old age and exquisite response to corticosteroids. RS3PE syndrome is a rare but well-defined syndrome known to be associated with solid tumors and haematologic malignancies. Recent research has shown that it is not a specific entity but rather a syndrome that can represent the inaugural form of various types of rheumatic disease and neoplastic conditions of the elderly. A thorough examination in elderly patients with RS3PE syndrome, and heightened suspicion of potential underlying malignant disease is necessary.


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Article Type: Review Article

Eur J Gen Med, 2004 - Volume 1 Issue 2, pp. 3-5

Publication date: 15 Apr 2004

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Article Downloads: 201

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