Multiple endocrine neoplasia type 1 with brown tumors as first manifestation in a patient with pituitary adenoma: A case report
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Katty Manrique-Franco 1 , Claudia Vanessa Ibarcena-Llerena 2 * , Geraldine Espinoza Gutierrez 3 , Diego Chambergo-Michilot 3
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1 Hospital Nacional Arzobispo Loayza, Lima, PERU2 Hospital Nacional Dos de Mayo, Lima, PERU3 Universidad Científica del Sur, Lima, PERU* Corresponding Author

Abstract

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is an infrequent autosomal dominant hereditary syndrome. Common manifestations are related to hypercalcemia, which is caused by primary hyperparathyroidism (PHPT). Brown tumors are infrequent as initial presentation of PHPT associated with MEN 1. It occurs in less than 2% of MEN 1 population.
Results: A 36-year-old woman started the disease 25 years ago in an insidious and progressive manner. She presented a soft tumor in the left malar region that progressively increased in volume. We treated recurrent multiple brown tumors in a patient with PHPT and pituitary adenoma.
Conclusion: The follow-up was demanding and multidisciplinary. The long-term prognosis is uncertain; therefore, close monitoring of the patient should be carried out through clinical, laboratory and imaging evaluation.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

ELECTRON J GEN MED, Volume 19, Issue 4, August 2022, Article No: em384

https://doi.org/10.29333/ejgm/12077

Publication date: 08 May 2022

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