Multiple endocrine neoplasia type 1 with brown tumors as first manifestation in a patient with pituitary adenoma: A case report
Katty Manrique-Franco 1, Claudia Vanessa Ibarcena-Llerena 2 * , Geraldine Espinoza Gutierrez 3, Diego Chambergo-Michilot 3
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1 Hospital Nacional Arzobispo Loayza, Lima, PERU
2 Hospital Nacional Dos de Mayo, Lima, PERU
3 Universidad Científica del Sur, Lima, PERU
* Corresponding Author


Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is an infrequent autosomal dominant hereditary syndrome. Common manifestations are related to hypercalcemia, which is caused by primary hyperparathyroidism (PHPT). Brown tumors are infrequent as initial presentation of PHPT associated with MEN 1. It occurs in less than 2% of MEN 1 population.
Results: A 36-year-old woman started the disease 25 years ago in an insidious and progressive manner. She presented a soft tumor in the left malar region that progressively increased in volume. We treated recurrent multiple brown tumors in a patient with PHPT and pituitary adenoma.
Conclusion: The follow-up was demanding and multidisciplinary. The long-term prognosis is uncertain; therefore, close monitoring of the patient should be carried out through clinical, laboratory and imaging evaluation.


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Article Type: Case Report

ELECTRON J GEN MED, 2022 - Volume 19 Issue 4, Article No: em384

Publication date: 08 May 2022

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Article Downloads: 218

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