Epidemiological and Molecular-Genetic Characteristics of the Measles Outbreak in Kazakhstan
Aygerim Zhuzzhasarova 1 * , Dinagul Bayesheva 1, Nurshay Azimbaeva 2, Manar Smagul 3, Gauhar Nusupbaeva 4, Bayan Turdalina 1, Aliya Seidullayeva 1, Bakhytzhan Abdullaev 5, Almagul Kushugulova 6 7
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1 Non-Profit Joint-Stock Company “Medical University of Astana”, Nur-Sultan, KAZAKHSTAN
2 Department of the Public Health Protection Committee of the Ministry of Health of the Republic of Kazakhstan, Nur-Sultan, KAZAKHSTAN
3 Department of Infectious and Parasitic Diseases of the National Center of Public Health, Nur-Sultan, KAZAKHSTAN
4 “Center for Sanitary and Epidemiological Expertise and Monitoring” of the RSE at the PEM “NCPH”, Almaty, KAZAKHSTAN
5 City Multidisciplinary Hospital No 1 of the Government of Nur-Sultan, Nur-Sultan, KAZAKHSTAN
6 National Laboratory Astana Nazarbayev University, Nur-Sultan, KAZAKHSTAN
7 Kazakhstan Society of Human Microbiome Researchers, Nur-Sultan, KAZAKHSTAN
* Corresponding Author

Abstract

Introduction: Genetic characterization of measles viruses (MVs) is an important component of laboratory surveillance of measles. In this study, a phylogenetic analysis was performed of the nucleoprotein gene sequences isolated in the Republic of Kazakhstan in 2018 year.
Objective: To study the epidemiological characteristics of measles and identify the circulating strain in the Republic of Kazakhstan during the period of increasing incidence for 36 global efforts to eliminate measles among the population.
Material and Methods: On the basis of the reference laboratory “Center for Sanitary and Epidemiological Expertise and Monitoring” of the RSE at the PEM “NCPH” genotyping of measles virus isolated from biological material (urine) from laboratory-confirmed cases was performed.
Results: According to the results of the study, it was revealed that the genotypes of the measles virus circulating in the Republic of Kazakhstan belong to two genotypes, the majority of samples (n=16) belonged to the D8genotype and2 samplesto the B3 genotype/MVi/Harare.ZWE/38.09./.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejgm/11549

ELECTRON J GEN MED, 2022 - Volume 19 Issue 2, Article No: em350

Publication date: 13 Jan 2022

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