Effect of Urtica Dioica against Doxorubicin-Induced Cardiotoxicity in Rats through Suppression of Histological Damage, Oxidative Stress and Lipid Peroxidation
Mustafa Erboga 1 * , Yeliz Bozdemir Donmez 2, Umit Sener 3, Zeynep Fidanol Erboga 1, Cevat Aktas 1, Mehmet Kanter 4
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1 Namık Kemal University, School of Medicine, Department of Histology and Embryology, Tekirdag, Turkey
2 Namık Kemal University, School of Medicine, Department of Physiology, Tekirdag, Turkey
3 Trakya University, Technology Research and Development Application and Research Center, Edirne, Turkey
4 Istanbul Medeniyet University, School of Medicine, Department of Histology and Embryology, Istanbul, Turkey
* Corresponding Author


Doxorubicin (DOX) is a highly effective anti-cancer drug with limited clinical use due to its serious cardiotoxicity. Urtica dioica L. seeds (UD), have been widely used in folk medicine, particularly in the therapy for advanced cancer patients, possesses a potent anti-oxidant properties. The goal of present study was to investigate the cardioprotective effects of UD on DOX-induced cardiotoxicity.

The rats in the UD treated group were given intraperitoneally 2 ml/kg UD. To induce cardiotoxicity, 30 mg/kg DOX was injected intraperitoneally by a single dose and the rats were sacrificed after 48 h.

The present study revealed for the first time a protective role of UD against DOX-induced cardiotoxicity. UD therapy significantly protected against DOX-induced myocardial damage which was characterized by conduction abnormalities, vacuolization, inflammatory cell infiltration, hemorrhages, and myofibrillar disarrangement. As indicators of oxidative stress, DOX caused significantly increase lipid peroxidation and reduction in activities of antioxidant enzymes; superoxide dismutase, glutathione peroxidase, and catalase. UD treatment significantly attenuated DOX-induced oxidative injury.

The present study showed that UD might be a suitable cardioprotector against toxic effects of DOX.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article


EUR J GEN MED, 2016 - Volume 13 Issue 2, pp. 139-144

Publication date: 06 Apr 2016

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