Clinical Features of COVID-19 Hospitalized Patients with and without Chronic Kidney Disease: A Single-Center, Cross-Sectional Study
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Morteza Ahmadzadeh-Darinsoo 1 , Mostafa Akbariqomi 1 , Mojtaba Ahmadzadeh-Darinsoo 1 , Reza Ranjbar 2 , Masoud Arabfard 3 , Ali Razei 4 , Soraya Shadmanfar 5 , Ahmad Khonche 6 , Mohsen Abbasi Farajzadeh 7 , Amir Homayoun Keihan 2 , Gholamreza Farnoosh 1 , Said Yaghoob Sehri 8 *
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1 Applied Biotechnology Research Centre, Baqiyatallah University of Medical Sciences, Tehran, IRAN2 Molecular Biology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IRAN3 Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IRAN4 Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, IRAN5 Rheumatology Department, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, IRAN6 Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, IRAN7 Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, IRAN8 Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran, IRAN* Corresponding Author

Abstract

Background and Objectives: The severity and mortality of coronavirus disease 19 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 are positively associated with underlying diseases such as hypertension, diabetes, and chronic kidney disease (CKD). In this regard, the current study aimed to evaluate the clinical characteristics, laboratory findings, and outcomes of coronavirus disease 2019 (COVID-19) hospitalized patients with and without CKD.
Methods: This cross-sectional matched study was conducted on hospitalized confirmed COVID-19 patients with and without CKD admitted to Baqiyatallah Hospital in Tehran, Iran, from February 26, 2020 to March 26, 2020. The patients were homogenized in terms of age, gender, body mass index, and underlying diseases such as hypertension and diabetes. Demographic data, clinical symptoms, and laboratory and radiological findings were collected from patients’ medical records and compared between the patients based on their CKD status.
Results: Among the COVID-19 patients, 56 and 97 cases with and without CKD were investigated, respectively. In general, 111 (72.5%) patients with a mean age of 55 years were males. Patients with CKD had higher levels of blood urea nitrogen, creatinine, and red cell distribution width (p<0.05). No differences were found regarding chest computed tomography findings, ICU admission, and death among COVID-19 patients with and without CKD.
Conclusions: Overall, the findings support the use of red cell distribution width, blood urea nitrogen, and creatinine for monitoring the COVID-19 patients with CKD and assessing the risk of disease progression. Eventually, managing comorbidities including hypertension and diabetes will reduce COVID-19 severity in CKD patients.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2022, Volume 19, Issue 2, Article No: em345

https://doi.org/10.29333/ejgm/11544

Publication date: 13 Jan 2022

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