Clinical and morphological changes of the spleen in COVID-19 patients with and without splenectomy
Full Text (PDF)
Anna Berestova 1 * , Marina Karagezyan 2 , Anastasiya Spaska 3 , Tatyana Sakharova 4 , Dariya Shorina 5
More Detail
1 Institute of Clinical Morphology and Digital Pathology, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA2 Institute of Linguistics and Intercultural Communication, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA3 Department of Basic Sciences, College of Medicine, Ajman University, Ajman, UAE4 Department of Biology and General Genetics, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA5 Department of Polyclinic Therapy, I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RUSSIA* Corresponding Author

Abstract

Patients diagnosed with COVID-19 were seen to develop splenic infarction or abscess. This study aims to estimate the incidence of splenic infarction/abscess in COVID-19 patients and to examine the clinical and morphological changes in the infected spleen. In the splenectomy group, 63.5% of patients had an enlarged spleen measuring between 12.1 cm × 5.1 cm and 19.2 cm × 12.2 cm. The incidence of splenic infarction was 36.4%, while the incidence of splenic infarction complicated by abscess was 18.1%. The size of splenic infarcts varied from 3.1 cm × 1.4 cm to 10.2 cm × 4.3 cm. Splenic abscesses were present in 72.3% of patients. Of 596 patients with severe COVID-19, 12 had at least one splenic abscess (2.3%): three patients had multiple splenic abscesses, while the rest had a single abscess pocket. Splenic infarction was found in 116 patients (22.5%), including 6 patients who later developed splenic abscesses.

Keywords

License

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 21, Issue 5, October 2024, Article No: em602

https://doi.org/10.29333/ejgm/14935

Publication date: 01 Sep 2024

Online publication date: 10 Aug 2024

Article Views: 450

Article Downloads: 402

Open Access References How to cite this article