Association of Mean Platelet Volume With The Degree of Retinopathy in Patients with Diabetes Mellitus
Orhan Ateş 1, İlhami Kiki 2, Habip Bilen 2, Mustafa Keleş 2, İbrahim Koçer 1, Destan Nil Kulaçoğlu 1, Orhan Baykal 1
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1 Department of Ophthalmology, University of Ataturk, School of Medicine, Erzurum, Turkey.
2 Department of Internal Medicine, University of Ataturk, School of Medicine, Erzurum, Turkey.


Aim: We investigated the association of mean platelet volume (MPV) with the degree of retinopathy in patients with diabetes mellitus (DM). Methods: Ninety patients with diabetic retinopathy (DRP) and 30 healthy individuals were included in the study. Diabetic patients included 30 background, 30 non-proliferative and 30 proliferative diabetic retinopathy cases. Complete blood count, intra- and intergroup comparisons of MPV values were performed. Results: Mean values for MPV in patients with background, nonproliferative and proliferative DRP were 7.76±0.72 fL, 7.94±0.61 fL and 8.18±0.89 fL, respectively. MPV values of patients with background DRP was not significantly different from that of the control group and patients with non-proliferative and proliferative DRP as well. However, MPV values of patients with proliferative DRP were significantly higher than the values of control group (p< 0.05). A significant correlation was found between the degree of retinopathy and mean values of MPV in diabetic patients (r= 0.214, p< 0.05). Conclusions: We found an association between the degree of retinopathy and mean values of MPV. This finding suggests a role for platelets in the pathogenesis of vascular complications and that mean platelet volume would be useful in monitoring the disease progression.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

Eur J Gen Med, 2009 - Volume 6 Issue 2, pp. 99-102

Publication date: 15 Apr 2009

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Article Downloads: 139

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