Association between P582S HIF-1A gene polymorphism and hematological parameters among women: A cross-sectional study
Zaid Z Akkoub 1 , Omar F Khabour 1 *
More Detail
1 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, JORDAN* Corresponding Author


Women are prone to low red blood indices due to increased physiological requirements and frequent blood loss in menstrual periods. Hypoxia-inducible factors (HIFs) act as master regulators of oxygen and iron balance. In this study, the association between P582S HIF-1A polymorphism and red blood indices among women was examined. A total of 310 participants were recruited in the study. PCR followed by RFLP technology was used to genotype HIF-1A polymorphism. The mean age of participants was 27.0 years, and the mean BMI was 26.4±7.73 kg/m2. Most of the participants did not exercise (89.1%), and about 21.1% were current tobacco smokers. Frequency of 582S (T) mutant allele was 17.5% while the frequency of 582P (C) wild-type allele was 82.5%. No association was found between P582S HIF-1A and hemoglobin level (p=0.37), red blood cell count (p=0.33), hematocrit (p=0.96), mean body size (p=0.20), mean corpuscular volume (p=0.34), mean corpuscular hemoglobin concentration (p=0.22), red blood cell distribution width (p=0.77), ferritin (p=0.19), and erythropoietin (p=0.15). In addition, no significant differences were found in distribution of P582S genotypes according to age of participants, body mass index, smoking status, and exercise habits (p>0.05). In conclusion, P582S HIF-1A polymorphism may not be associated with red blood indices among women. More studies in other populations are needed to confirm this finding.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2023, Volume 20, Issue 5, Article No: em508

Publication date: 01 Sep 2023

Online publication date: 16 May 2023

Article Views: 716

Article Downloads: 665

Open Access References How to cite this article