An Updated Overview of Herpes Simplex Virus-1 Infection: Insights from Origin to Mitigation Measures
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Abu Tayab Moin 1, Mohammad Al-baruni Chowdhury 1, Sumaiya Hafiz Riana 1, Md. Asad Ullah 2, Yusha Araf 3, Bishajit Sarkar 2, Abdullah Mohammad Shohael 2 *
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1 Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chattogram, BANGLADESH
2 Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Dhaka, BANGLADESH
3 Department of Genetic Engineering and Biotechnology, Faculty of Life Sciences, Shahjalal University of Science and Technology, Sylhet, BANGLADESH
* Corresponding Author

Abstract

Purpose: High prevalence of recurrent HSV-1 (Herpes Simplex Virus 1) and its facile mode of transmission requires an elaborated understanding of the virus for mollification. To mitigate its pervasive nature that greatly affects both men and women, a thorough understanding of the viral genome and epidemiology are prerequisites. The review focuses on the existing facts of HSV-1 and acknowledges the prospect of ongoing epidemiological studies.
Findings: Recent data indicates a surge of HSV-1 infection in the age ranged 30-50 years along with the emergence of neonatal cases. The newfound receptors indicate the effect and degree of susceptibility of the host and support the statistical data of HSV-1 seropositivity. Recent studies also show that the evolving virus has gained resistance against widely used antiviral drugs such as Acyclovir (ACV). Therefore, trials of several vaccines (eg. GEN-003and HerpV) are garnering attention as a possible prevention method.
Summary: As most natural viruses are radically evolving, ensuing rather fatal consequences than previous wild types, every virus requires to be tackled with equal importance. Developing vaccines and potent drugs to eradicate viruses from infected subjects’ systems can be the only way to prevent future viral epidemics or pandemics. Therefore, early detection of the virus with accurate assay following immediate treatment can only prevent the cases from future catastrophe.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review Article

https://doi.org/10.29333/ejgm/10869

ELECTRON J GEN MED, 2021 - Volume 18 Issue 4, Article No: em299

Publication date: 01 May 2021

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Article Downloads: 2169

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