Thiol Disulfide Balance Oxidative Stress and Paraoxonase 1 Activities in Children and Adolescents Aged 6-16 Years with Specific Learning Disorders
Hasan Basri Savas 1 * , Ersin Sayar 2 , Tayfun Kara 3
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1 Alanya Alaaddin Keykubat University, Medical Faculty, Department of Medical Biochemistry, Antalya, TURKEY2 Istanbul Kanuni Sultan Suleyman Educational and Research Hospital, Department of Pediatric Gastroenterology, Istanbul, TURKEY3 Alanya Alaaddin Keykubat University, Medical Faculty, Department of Child and Adolescent Psychiatry, Antalya, TURKEY* Corresponding Author


Introduction: Specific learning disorders (SLD) are some of the most common neurodevelopmental disorders. The aim of this study is to determine the potential relationship between children with SLD and zinc, copper, paraoxonase 1 (PON1), arylesterase (ARY), ischemia-modified albumin, thiol balance, oxidative stress index, total antioxidant status, total oxidant status, and routine biochemical parameters.
Methods: All participants were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children. Total oxidant status, total antioxidant status, thiol balance, ischemia modified albumin, paraoxonase 1 activity, arylesterase activity, zinc and copper levels were measured by the spectrophotometric methods.
Results: Compared to the control, the SLD group had statistically significantly lower values for PON1 antioxidant enzyme activity (p=.045), ARY antioxidant enzyme activity (p<.001), 25 OH Vitamin D (p=.005), reduced thiol ratio (p=.028), thiol oxidation reduction ratio (p=.01), native thiols (p=.024) and significantly higher values for total oxidant status (p=.017), oxidized thiol ratio (p=.028).
Conclusion: The relationship between oxidative stress and SLD diagnosis in our results will be very important if it is supported by further new studies. In this case, evaluation of vitamin D, oxidative stress, antioxidant status and thiol balance may come to the agenda in the diagnosis and treatment of SLD.


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Article Type: Original Article

ELECTRON J GEN MED, 2021, Volume 18, Issue 3, Article No: em290

Publication date: 15 Apr 2021

Article Views: 1393

Article Downloads: 1248

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