The Relationship between Oxidative Stress and Coronary Artery Calcification in Patients Undergoing Peritoneal Dialysis or Hemodialysis
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Fatih Mehmet Erdur 1 * , Kultigin Turkmen 2, Hatice Kayikcioglu 3, Fatih Ozcicek 4, Aysun Toker 5, Orhan Ozbek 6, Suleyman Turk 1, Halil Zeki Tonbul 1
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1 Department of Nephrology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey2 Department of Nephrology, Mengucek Gazi Training and Research Hospital, Erzincan, University, Erzincan, Turkey3 Department of Internal Medicine, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey4 Department of Internal Medicine, Mengucek Gazi Training and Research Hospital, Erzincan University, Erzincan, Turkey5 Department of Biochemistry, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey6 Department of Radiology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey* Corresponding Author

Abstract

Vascular calcification and increased oxidative stress are commonly seen in patients with end-stage renal disease (ESRD). Nitrotyrosine is one of the end products of nitric oxide metabolism and is accepted as an indicator of oxidative stress. Nitrotyrosine levels have been found to be high in ESRD patients. The aim of our study is to investigate the relation between coronary artery calcification and oxidative stress in peritoneal dialysis (PD) and hemodialysis (HD) patients. 46 PD and 34 HD patients are included in the study. Coronary artery calcification scoring (CACS) is made by multi slice computed tomography. Patients are divided into 4 groups according to their CACS values as Group 1 (CACS: 0), Group 2 (CACS:1-99), Group 3 (CACS:100-399) and Group 4 (CACS: ≥400). Serum nitrotyrosine levels were measured. Nitrotyrosine levels were significantly increased in HD patients compared to PD patients. Nitrotyrosine levels were found to be elevated in accordance with increased CACS in PD patients. However, we could not find this relationship in HD patients. There might be an important relationship between CACS and oxidative stress in PD patients.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, Volume 12, Issue 1, January 2015, 53-58

https://doi.org/10.15197/sabad.1.12.09

Publication date: 07 Jan 2015

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