The predictors of prognostic nutritional index and its association with in-hospital mortality among critically ill geriatric patients
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Khalid Elsayed Elsorady 1 2 * , Ahmed Ahmed Mohamed Abotaha 3 , Mohammed Abdelmoaty Ebrahim Shaheen 4 , Hisham Ahmed Hani Mostafa Abdelaziz 4 , Essam Yehia Ali Aggour 3 , Mohamed Elwan Mohamed Mahmoud 3
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1 Department of Geriatrics and Gerontology, Faculty of Medicine, Ain Shams University, Cairo, EGYPT2 Geriatrics Hospital, Ain Shams University Hospitals, Cairo, EGYPT3 Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, EGYPT4 Department of Clinical Pathology, Faculty of Medicine, Al-Azhar University, Cairo, EGYPT* Corresponding Author

Abstract

Purpose: The study aimed to determine the predictors of prognostic nutritional index (PNI) and its association with in-hospital mortality among critically ill geriatric patients
Materials and methods: Prospective cohort study included 113 critically ill older patients at a geriatrics hospital in Egypt. Clinical history, laboratory analyses, Charlson comorbidity index, and simplified acute physiology score II were conducted on admission. Immuno-nutritional biomarkers included PNI, neutrophil/lymphocyte ratio (NLR), systemic immune inflammation index (SII), and platelet/lymphocyte ratio (PLR). The hospital outcome was in-hospital mortality.
Results: Median PNI was 33.45. Predictors of PNI were albumin and hematocrit. PNI showed a negative correlation with NLR (r = -0.475, p < 0.001), PLR (r = -0.263, p = 0.005), and SII (r = -0.287, p = 0.002). PNI < 35.475 and NLR > 6.5 defined in-hospital mortality with an area under the curve of 0.633, p = 0.011 and p = 0.612, p = 0.036, respectively.
Conclusion: PNI < 35.475 and NLR > 6.5 are associated with in-hospital mortality. PNI had an inverse correlation with NLR, SII, and PLR.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 22, Issue 4, August 2025, Article No: em656

https://doi.org/10.29333/ejgm/16303

Publication date: 01 Jul 2025

Online publication date: 30 Apr 2025

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