The Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease
Bulent Bilir 1 * , Nejat Altıntaş 1, Murat Aydın 1, Mustafa Oran 1, Savas Özsu 2, Ümit Tutar 3
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1 Namik Kemal University School of Medicine, Tekirdağ, Turkey
2 Karadeniz Technical University School of Medicine, Trabzon, Turkey
3 Republic of Turkey Ministry of Health, State of Pulmonary Disease of Hospital, Samsun, Turkey
* Corresponding Author


Recently neutrophil-to-lymphocyte ratio (NLR) -the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status.In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated.

We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people.C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cut-off value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant.

By spearman analysis, there was a strong correlation between.C-Reactive protein and N/L ratio in both stable group (r=0.436, p<0.001) and exacerbation group (r=0.534, p=0.001).

Neutrophil/lymphocyte ratio may bea useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2016 - Volume 13 Issue 2, pp. 105-110

Publication date: 06 Apr 2016

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