The pathological and immunohistochemical profile of tumor angiogenesis in perforated sigmoid carcinoma–Case report and short literature review
Raul Mihailov 1 2 , Adrian Beznea 1 2 , Constantin Popazu 2 , Dragoș Voicu 2 , Alexandra Toma 2 , Iulia Tudorașcu 3 , Laura Rebegea 2 , Oana Mariana Mihailov 2 , Valerii Lutenco 1 2 , Georgiana Bianca Constantin 2 * , George Țocu 2 , Elena Niculeț 2 , Rodica Bîrlă 4 , Dragoș Eugen Georgescu 4 5 , Cristina Șerban 1 2
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1 Surgery Clinic, “Sf. Ap. Andrei” Emergency Clinical Hospital, Galati, ROMANIA2 Faculty of Medicine and Pharmacy, “Dunarea de Jos” University, Galati, ROMANIA3 University of Medicine and Pharmacy of Craiova, Craiova, ROMANIA4 “Carol Davila” University of Medicine and Pharmacy, Bucharest, ROMANIA5 Department of General Surgery, Dr. Ion Cantacuzino Hospital, Bucharest, ROMANIA* Corresponding Author

Abstract

Background: Little is known about the physiopathological factors or mechanisms that underlie tumor invasion of the serosa and lead to perforation in the peritoneal cavity. The aim of the work was to analyze the pathological and immunohistochemical factors of tumor neoangiogenesis which could influence tumor perforation in colorectal cancer.
Results and discussions: 451 cases of complicated colorectal carcinomas were statistically analyzed, of which 19 cases were perforated sigmoid tumors. The immunohistochemical detection of mutant p53 proteins was the first molecular parameter examined in the context of the search for markers predicting the natural evolution mode in colorectal carcinomas.
Conclusions: Both loss of p53 and overexpression of bcl-2 proteins confer immortalization on cancer cells by inhibiting the processes leading to apoptosis. The paper proposes a review of the specialized literature, but also the presentation of a clinical case.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

ELECTRON J GEN MED, Volume 21, Issue 5, October 2024, Article No: em600

https://doi.org/10.29333/ejgm/14847

Publication date: 01 Sep 2024

Online publication date: 16 Jul 2024

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