The Mechanisms of the Direct Vascular Effects of Sevoflurane on Saphenous Veins in Vitro
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Havva Feyza Ölçer 1, Atilla Erol 1 * , Ayşe Ş. Şahin 2, Şeref Otelcioğlu 1
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1 Selcuk University, Medical School, Department of Aneasthesiology, Konya, Turkey2 Selcuk University, Medical School, Department of Pharmacology, Konya, Turkey* Corresponding Author

Abstract

Aim: The purpose of this study was to determine the mechanism of the directs effects of sevoflurane on human veins in vitro. Methods: Dose-response curves were obtained for cumulative doses of sevoflurane (0.5, 1, 1.5 and 2 MAC) on saphenous vein strips precontracted with 5-hydroxytryptamine ( 5-HT 10-6 mol/L) incubated with either Nω-nitroL-arginine-methyl ester (L-NAME) (10-4 mol/L), indomethacine (10-5 mol/L), glibenclamide (10-6 mol/L) or tetraethylammonium (10-4 mol/L) Results: Preincubation of vein strips with tetraethylammonium (TEA, Ca++-activated K+ channel blocker) did not influence the relaxant responses to sevoflurane (p>0.05). L-NAME, indomethacine and glibenclamide reduced the relaxation response to sevoflurane (p<0.05). Conclusion: Our results demonstrated that sevoflurane produces concentration dependent relaxation in human saphenous vein. The relaxant effects of sevoflurane are probably related with activation of nitric oxide synthase, cyclooxygenase and KATP channels pathways.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2009, Volume 6, Issue 1, 1-5

https://doi.org/10.29333/ejgm/82627

Publication date: 15 Jan 2009

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