The Importance of Natural ACE2 Inhibitor: Potency of Porang (Amorphophallus muelleri) Glucomannan as Anti-SARS-Cov-2
Amira Hasnanuha Ulayya 1 * , Ahmad Zaki Mubarok 1, Widodo Widodo 2 * , Simon Bambang Widjanarko 1, Marlita Marlita 2
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1 Faculty of Agricultural Technology, Universitas Brawijaya, INDONESIA
2 Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, INDONESIA
* Corresponding Author


The inhibition of SARS-Cov-2 S binding with hACE2, expressed in most human tissues, may prevent the severity of virus infection. However, commercial ACE2 inhibitor drugs are still limited, while several natural compounds have already been reported to have anti-ACE2 activity. We found the potential of hydrolyzed glucomannan of porang tuber in the inhabitation of binding activity between ACE2 and S1 of SARS-Cov-2.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Short Communication

ELECTRON J GEN MED, 2022 - Volume 19 Issue 1, Article No: em340

Publication date: 02 Dec 2021

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