The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders

Dmitry Maltsev

doi:10.29333/ejgm/16719

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Dmitry Maltsev ¹ ^*

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¹ Scientific Research Institute of Experimental and Clinical Medicine, O. O. Bogomolets National Medical University, Kyiv, UKRAINE^* Corresponding Author

Abstract

The present study aims to evaluate the efficacy and safety of combination immunocorrection with transfer factors in autism spectrum disorders (ASD) children with genetic deficiency of the folate cycle (GDFC) and natural killer (NK) and/or natural killer T-lymphocyte (NKT) cell deficiency. The single-center, retrospective, controlled, non-randomized clinical trial analyzed medical records of 225 ASD children with GDFC aged 2-9 years. SG received the transfer factor classic in dose 2 caps 3 times a day and transfer factor trifactor in dose 1 caps 3 times a day during 3 months. The control group involved 52 ASD children with GDFC who followed the same age and gender distribution pattern but did not receive immunocorrection. The number of NK cells reached the lower limit of reference range in 109 out of 146 patients (75% of cases) with baseline deficiency of these lymphocytes. The combination of transfer factors is an effective and safe strategy for NK- and NKT-cell deficiency correction in children with ASD.

Keywords

immune status
immunocorrection
immunoprophylaxis

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 22, Issue 5, October 2025, Article No: em678

https://doi.org/10.29333/ejgm/16719

Publication date: 01 Sep 2025

Online publication date: 01 Aug 2025

Article Views: 461

Article Downloads: 516

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How to cite this article

Vancouver

Maltsev D. The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders. ELECTRON J GEN MED. 2025;22(5):em678. https://doi.org/10.29333/ejgm/16719

APA

Maltsev, D. (2025). The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders. Electronic Journal of General Medicine, 22(5), em678. https://doi.org/10.29333/ejgm/16719

AMA

Maltsev D. The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders. ELECTRON J GEN MED. 2025;22(5), em678. https://doi.org/10.29333/ejgm/16719

Chicago

Maltsev, Dmitry. "The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders". Electronic Journal of General Medicine 2025 22 no. 5 (2025): em678. https://doi.org/10.29333/ejgm/16719

Harvard

Maltsev, D. (2025). The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders. Electronic Journal of General Medicine, 22(5), em678. https://doi.org/10.29333/ejgm/16719

MLA

Maltsev, Dmitry "The effectiveness of combined application of transfer factors in natural killers and natural killers T-cells deficiency in children with autism spectrum disorders". Electronic Journal of General Medicine, vol. 22, no. 5, 2025, em678. https://doi.org/10.29333/ejgm/16719