The diagnosis of LADA diabetes in a low-resource country: A Peruvian case series
Juan Eduardo Quiroz-Aldave 1 , María del Carmen Durand-Vásquez 2 , Sofía Pilar Ildefonso-Najarro 3 , Elman Rolando Gamarra-Osorio 4 , Susan Luciana Puelles-León 5 , Cyntia Mileini Quesquén-García 6 , Luis Alberto Concepción-Urteaga 7 , José Paz-Ibarra 8 9 , Elena Alvarado-León 7 , Edi William Aguilar Urbina 7 , Augusto Aldave Herrera 7 , Marcio José Concepción-Zavaleta 10 *
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1 Estrategia Sanitaria de Daños No Transmisibles, Hospital de Apoyo Chepén, Chepén, PERU2 Centro de Salud Mental Comunitario “Abraza la Vida”, Chepén, PERU3 Servicio de Endocrinología, Hospital Nacional Guillermo Almenara Irigoyen, Lima, PERU4 Servicio de Endocrinología, Hospital Víctor Lazarte Echegaray, Trujillo, PERU5 Servicio de Medicina, Hospital de Apoyo Chepén, Chepén, PERU6 Red Integrada de Salud Chepén, Chepén, PERU7 Facultad de Medicina, Universidad Nacional de Trujillo, Trujillo, PERU8 Servicio de Endocrinología, Hospital Edgardo Rebagliati Martins, Lima, PERU9 Departamento de Medicina, Escuela de Medicina, Universidad Nacional Mayor de San Marcos, Lima, PERU10 Universidad Científica del Sur, Lima, PERU* Corresponding Author

Abstract

Introduction: Diabetes mellitus (DM) is a global public health concern, affecting 10% of adults. Among its variants, latent autoimmune diabetes in adults (LADA) accounts for 3% to 11% of cases. Limited awareness and high testing costs contribute to misdiagnosis and inadequate treatment, increasing the risk of chronic complications.
Design: A cases series.
Methods: Fifteen Peruvian patients with LADA were studied to describe their clinical presentation, diagnosis, and treatment.
Results: The average age was 36.2 years, with a mean disease duration of 5.6 years. All patients presented with acute symptoms, and their mean body mass index at diagnosis was 23.3 kg/m². Glycemic control was achieved with an average daily insulin dose of 0.96 IU/kg. None of the patients had access to capillary glucose self-monitoring or continuous glucose monitoring, as all were living in poverty or extreme poverty.
Conclusions: LADA is an uncommon form of early-onset DM whose diagnosis and treatment in resource-limited countries are impacted by socioeconomic conditions. Therefore, we propose a clinical algorithm for managing this condition in low-resource settings.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

ELECTRON J GEN MED, Volume 22, Issue 4, August 2025, Article No: em653

https://doi.org/10.29333/ejgm/16301

Publication date: 01 Jul 2025

Online publication date: 30 Apr 2025

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Article Downloads: 9

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