The Chromophobe Renal Cell Carcinoma with Sarcomatoid Differentiation
Sefa Resim 1 * , Sevgi Bakaris 2, Rana Citil 2, Erkan Efe 1, Can Benlioglu 3
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1 Department of Urology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, Kahramanmaras, Turkey
2 Department of Pathology, Kahramanmaras Sutcu Imam University, Faculty of Medicine, 46050 Kahramanmaras, Turkey
3 Can Benlioglu, M.D. Department of Urology, 7 Mart Hospital, Kadirli, Turkey
* Corresponding Author


We present a rare case of a 52-year-old woman with a chromofobe renal cell carcinoma that had sarcomatoid components. The tumor, 70x60mm in size, was incidentally found by abdominal ultrasonography. An abdominal computed tomography demonstrated a well-demarcated solid tumor arising from the upper pole of the right kidney. Histologically, the tumor was composed of two intermixed distinct morphologic components: a chromophobe renal cell carcinoma and a high-grade spindle cell sarcoma. There was a sarcomatoid area composed of highly atypical spindle cells intermingled with rhabdoid cells. A unique histological finding of this tumor was the presence of calcification and psammoma body formation throughout the tumor. We think that this case supports the existence of a tumor progression pathway from chromofob to sarcomatoid renal cell carcinoma. A literature review on sarcomatoid chromofobe renal cell carcinoma with calcification was performed


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Article Type: Case Report

EUR J GEN MED, 2014 - Volume 11 Issue Supplement 1, pp. 14-17

Publication date: 08 Jan 2014

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