THE CHANGES OF ZINC, COPPER, AND IRON LEVELS IN LUNG TISSUE AFTER FORMALDEHYDE INHALATION DURING THE EARLY POSTNATAL PERIOD OF RATS
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Ahmet Songur 1 * , İlter Kuş 2, Şemsettin Şahin 3, Sadık Söğüt 4, Oğuz Aslan Özen 1, Mehmet Yaman 5, Mustafa Sarsılmaz 2
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1 Afyon Kocapete University, Faculty of Medicine, Department of Anatomy, Afyon, Turkey2 Fırat University, Faculty of Medicine, Department of Anatomy, Elazığ, Turkey3 Gaziosmanpaşa University, Faculty of Medicine, Department of Biochemistry, Tokat, Turkey4 Mustafa Kemal University, Faculty of Medicine, Department of Biochemistry, Hatay, Turkey5 Firat University, Faculty of Science and Arts, Department of Chemistry, Elazığ, Turkey* Corresponding Author

Abstract

Aim: In this study, effects of inhaled formaldehyde (FA) gas, during early postnatal period on the levels of zinc, copper and iron elements and activity of total superoxide dismutase (t-SOD) enzyme in lung tissue and also the reversibility of effects of formaldehyde were examined. Methods: For this purpose newly born albino Wistar rats were exposed to 0 (control), 6 or 12 ppm FA gas for 30 days. After the treatment, rats were decapitated in 30th and 90th days. Activities of t-SOD and the levels of zinc, copper and iron were measured in lung samples. Results: A decrease in the t-SOD activity, copper and iron levels and increase in zinc levels were found in the treatment groups in comparison with control group at both 30th and 90th days measurements. Conclusion: It was thought that exposure to FA may alter the trace element levels of lung tissue including copper, zinc and iron, and induce further oxidative damage on lung tissue.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2005, Volume 2, Issue 2, 62-68

https://doi.org/10.29333/ejgm/82271

Publication date: 15 Apr 2005

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