The Association Between Polymorphism of Lys198Asn of Endothelin-1 Gene and Arterial Hypertension Risk in Kazakh People
A.U. Dzholdasbekova 1, A.E. Gaipov 2 *
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1 National Research Institute of Cardiology and Internal Diseases of Ministry of Health of Republic of Kazakhstan, Almaty, Kazakhstan
2 National Scientific Medical Centre of Ministry of Health of Republic of Kazakhstan, Astana, Kazakhstan
* Corresponding Author


Aim: We researched frequency distribution of genotypes and alleles Lys198Asn of polymorphism of endothelin -1 gene associated with arterial hypertension development in Kazakh people Method: The research included 120 patients suffering arterial hypertension of 2-3 degree, average, high and very high degree of risk, and control group included 80 actually healthy person of Kazakh nationality. Result: The research discovered that development of arterial hypertension in the present ethnic group associated with polymorphism of endothelin-1 gene. Conclusion: At that, allele 198Asn and AsnAsn genotype of endothelin-1 gene act as marker of increased risk of arterial hypertension development.


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Article Type: Original Article

EUR J GEN MED, 2010 - Volume 7 Issue 2, pp. 187-191

Publication date: 12 Apr 2010

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