SINGLE DOSE OF TIOTROPIUM DOES NOT EFFECT HEART RATE VARIABILITY
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Mehmet Unlu 1 * , Mehmet Melek 2, Fatma Fidan 1, Celal Kilit 2, Levent Tetik 1, Dayimi Kaya 3
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1 Afyon Kocatepe University, School of Medicine, Departments of Chest Disease, Afyon, Turkey2 Afyon Kocatepe University, School of Medicine, Departments of Cardiology, Afyon, Turkey3 Department of Cardiology, Ege Saglik Hospital, Izmir, Turkey* Corresponding Author

Abstract

Aim: Anticholinergic drugs may alter cardiac autonomic modulation. The aim of this study was to investigate the effects of inhaled tiotropium on heart rate variability (HRV). Methods: A randomized, double-blind, crossover design study was conducted on 11 healthy volunteers. Tiotropium or placebo was administered in two different testing sessions. Time domain parameters; mean R-R interval (mean-RR), the standard deviation of R-R interval (SDNN) and the root mean square of successive R-R interval differences (RMSSD) and power spectral analysis of HRV were assessed in the supine position, during handgrip exercise and controlled breathing before and after drug administration. Results: There were no statistically significant difference in baseline HRV parameters obtained before each drug administration (p >0.05). HRV parameters obtained after each drug administration were found not to be different during supine position, controlled breathing and handgrip exercise. Conclusion: Administration of single dose tiotropium did not effect cardiac autonomic modulations in healthy volunteers.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2006, Volume 3, Issue 3, 102-107

https://doi.org/10.29333/ejgm/82388

Publication date: 15 Jul 2006

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