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Abstract
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder with significant metabolic components, particularly insulin resistance (IR). Irisin and betatrophin have been proposed as novel metabolic regulators.
Methods: Patient selection was performed retrospectively, while the study was designed prospectively. Sixty women (20 PCOS, 20 PCOS+IR, 20 controls) were included. Plasma irisin and betatrophin levels were measured using ELISA. Clinical, biochemical, and hormonal parameters were analyzed, and correlations with metabolic markers were evaluated.
Results: Irisin levels were significantly higher in the PCOS+IR group, while betatrophin levels were significantly lower in both PCOS groups compared to controls. Irisin showed a positive correlation with body mass index (BMI), whereas betatrophin showed no significant correlation with BMI. No correlation was observed between irisin and betatrophin.
Conclusion: Irisin and betatrophin exhibit distinct and independent alterations in PCOS. These biomarkers may contribute to improved metabolic phenotyping and risk assessment in PCOS.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Type: Original Article
ELECTRON J GEN MED, Volume 23, Issue 3, June 2026, Article No: em733
https://doi.org/10.29333/ejgm/18521
Publication date: 05 May 2026
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