Rosuvastatin and RM-1 polyphenol effects on insulin resistance, coagulation, and platelet aggregation in diabetic rats
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Siroj S Khodjiyev 1 * , Guli M Raimova 1 , Muhammadqodir Musajonugli Ortiqov 1 , Islom B Qozoqov 1 , Jobir I Dedaboyev 1 , Nozimjon N Khoshimov 1 , Qobil E Nasirov 1 , Alisher A Mukhtorov 2 , Nazifa R Achilova 3 , Lola S Sadilloyeva 4
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1 Institute of Biophysics and Biochemistry, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTAN2 National University of Uzbekistan named after Mirzo Ulugbek, Tashkent, UZBEKISTAN3 Department of Biology, Faculty of Natural Sciences and Medicine, Navoi State University, Navoi, UZBEKISTAN4 Department of Natural and Technical Sciences, Navoi Innovations University, Navoi, UZBEKISTAN* Corresponding Author

Abstract

Background: Type 2 diabetes mellitus is associated with disturbances in carbohydrate and lipid metabolism as well as hemostasis, including hyperfibrinogenemia and enhanced platelet aggregation. Statins, while cardioprotective, may impair insulin secretion and increase insulin resistance (IR).
Aim: To evaluate the effects of rosuvastatin alone and in combination with RM-1 polyphenol on IR, lipid and hepatic parameters, coagulation, plasma fibrinogen, and platelet aggregation in a high-fat diet/streptozotocin-induced rat model of type 2 diabetes.
Methods: Forty male Wistar rats (280-320 g) were divided into four groups (n = 10 each): intact, diabetic control, diabetic + rosuvastatin (10 mg/kg/day), and diabetic + rosuvastatin + RM-1 (10 mg/kg/day each), treated orally for 4 weeks.
Results: Diabetic rats showed marked hyperglycemia, dyslipidemia, elevated liver enzymes, hyperinsulinemia with increased HOMA-IR, shortened APTT and PT, hyperfibrinogenemia (4.4 vs 2.1 g/L in intact rats), and enhanced platelet aggregation. Rosuvastatin partially corrected these parameters; the rosuvastatin + RM-1 combination produced the most consistent improvement, approaching intact-group values, and also improved ALT, AST, low-density lipoprotein, and HDL beyond rosuvastatin alone. Effects on triglycerides and total cholesterol were less uniform.
Conclusion: RM-1 polyphenol enhances the corrective effect of rosuvastatin on diabetes-induced glycemic and hemostatic disturbances, supporting its potential as an adjunct therapy.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 23, Issue 5, October 2026, Article No: em755

https://doi.org/10.29333/ejgm/19445

Publication date: 27 Sep 2026

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