Role of Subgroup Incompatibility in Newborn Jaundice Requiring Exchange Transfusion
Ali Annagür 1 * , Hüseyin Altunhan 2, Murat Konak 2, Hasan Koç 2, Rahmi Örs 2
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1 Department of Neonatology, Selcuk University Faculty of Medicine, Konya,Turkey
2 Department of Neonatology, Necmettin Erbakan University Meram Medical Faculty, Konya. Turkey
* Corresponding Author

Abstract

We aimed to determine the role of exchange transfusion related complications, treatment, and etiology as well as subgroup incompatibility in patients subject to ET (exchange transfusion) due to newborn jaundice. 82 patients hospitalized due to newborn jaundice and exposed to exchange transfusion between August 2007 and August 2011 were retrospectively studied. Before ET mean total serum bilirubin was 29,2±9,83. The most frequent cause of ET was ABO incompatibility (31%) followed by Rh incompatibility (19%) and subgroup incompatibility (17%), respectively. In 46% of all patients and in 71% of the patients presenting with subgroup incompatibility , direct combs test was detected to be (+). 49% of the patients were administrated with intravenous immunoglobulin. 5 of the patients who were exposed to ET presented with hydrops fetalis. Of these patients 3 had Rh, 1 had ABO while the other had subgroup incompatibility. Although ABO and Rh incompatibility are substantial underlying reasons of severe jaundice requiring exchange transfusion, particularly widespread use of RhoGAM thereby enabling the prior identification and precautions, ET need was reduced compared to previous cases. On the contrary, SGU related severe hemolytic jaundice relatively enhanced, however.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.15197/sabad.1.11.41

EUR J GEN MED, 2014 - Volume 11 Issue 2, pp. 66-70

Publication date: 15 Apr 2014

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