Rickets, vitamin D deficiency, adolescents
Celal Yavuz 1 * , Ömer Çakır 1, Mustafa Göz 1, Ebru Kale 1, Ali Kemal Uzunlar 1
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1 Dicle University, Medical School, Diyarbakır, Turkey
* Corresponding Author


Aim: The aim of this study was to investigate the effects of sodium nitroprussid (SNP) on ischemia-reperfusion injury in rats. Method: Twenty-four Sprague-Dawney rats were divided into four equal groups: group I without ischemia-reperfusion (I-R); group II with ischemia; group III with I-R; group IV with I-R and SNP. Complete bilateral hindlimb ischemia was produced by means of tourniquet occlusion of the upper thigh. Result: Blood creatine phosphokinase, lactate dehydrogenase, aspartate transaminase, urea, creatinine levels were not significantly different between groups 3 and 4. Malondialdehyde (MDA) levels were not significantly different between groups 3 and 4 in liver, soleus muscles and lung tissue. However, MDA levels were significantly lower in group 4 when compared with group 3 in renal tissue. Histological examination of the soleus muscles revealed that neutrophil leukocyte infiltration in group 3 was significantly less prominent than in group 4. Conclusion: These results have shown that SNP was not able to improve muscle ischemia-reperfusion injury in our study.


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Article Type: Original Article


EUR J GEN MED, 2010 - Volume 7 Issue 1, pp. 76-80

Publication date: 12 Jan 2010

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