Relation between homocysteine-to-adropin ratio and severity of coronary artery disease
Ola Hassan Abd Elaziz 1 * , Bassem Mohamed Abdel Hady 1 , Ghada Mohamed S Ahmad 1 , Safaa Abo Alfadl Mohamed 1 , Abeer Ahmed Elmalah 1 , Inass Hassan Ahmad 2 , Entesar O Elsaghier 2 , Marwa FM Elsayed 3 , Hala Naguib Mohamed 4 , Marwa Khairy Abd Elwahab 5 , Ahmed Salah 6
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1 Department of Cardiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT2 Department of Endocrinology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT3 Endocrinology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt4 Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT5 Department of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EGYPT6 Department of Cardiology, Faculty of Medicine, October 6 University, October 6 City, EGYPT* Corresponding Author

Abstract

Purpose: This study aimed to uncover if homocysteine (Hcy) adropin balance expressed by homocysteine/adropin ratio (HAR) is related to severity of disease in coronary artery disease (CAD) patients.
Materials & Methods: The present cross-sectional study 50 consecutive patients with low/intermediate CAD severity and other 50 patients with severe CAD. Hcy and adropin levels were assessed using commercially available kits.
Results: Patients with low/moderate severity CAD expressed significantly lower HAR. According to HAR, all patients were classified into those with low HAR (<median) and high HAR (≥HAR). Comparison between these subgroups revealed that patients with low HAR had significantly lower number of affected vessels and lower SYNTAX score. Also, it was found that HAR is correlated with SYNTAX scores in all patients and in patients with severe CAD.
Conclusions: Hcy and adropin levels are interlinked, HAR can effectively distinguish severe from non-severe CAD.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2024, Volume 21, Issue 1, Article No: em556

https://doi.org/10.29333/ejgm/13964

Publication date: 01 Jan 2024

Online publication date: 06 Dec 2023

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