Relation between airway cellular and bacterial findings and severity of COPD exacerbations: A multicentric study
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Sawsan Bakr Elsawy 1 , Khadiga Salama Mohamed 1 , Eman M Moazen 1 * , Sanaa Fathy Kotb 1 , Amira Mohammad Elsadek Ateya Elsayed 1 , Fatma Gamal Elsayed 1 , Eid Mohammed Mahmoud Mohammed 1 , Ragy Mamdouh Ghaly 2 , Entsar Rafaat Mokhtar 3 , Marwa A Elsaid 3 , Rania Hamid Bahi 4
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1 Department of Chest Diseases, Al-Azhar University, Cairo, EGYPT2 Department of Chest Diseases, Ain Shams University, Cairo, EGYPT3 Department of Clinical Pathology, Al-Azhar University, Cairo, EGYPT4 Department of Chest Diseases, Zagazig University, Zagazig, EGYPT* Corresponding Author

Abstract

Aim: To evaluate the relationships between sputum and bronchoalveolar lavage (BAL) cellular and bacterial findings and severity of exacerbation of chronic obstructive pulmonary disease (ECOPD).
Patients & methods: A cross-section study was conducted on 307 patients with ECOPD. They underwent sputum and BAL inflammatory cell count and bacterial culture.
Results: Patients with severe ECOPD have significantly higher neutrophils percentage (neut.%), lower lymphocytes percentage (lymph.%), lower eosinophils percentage (eosin.%) and higher neutrophil/lymphocyte ratio (NLR) as compared to patients with mild ECOPD. It was also shown that patients with severe ECOPD had significantly higher BAL neut.%, lower lymph.%, lower eosin.%, and higher NLR as compared to the other two subgroups. Also, patients with severe ECOPD have significantly higher frequency of cases with monomicrobial (71.30% vs. 36.10%) and polymicrobial (21.25% vs. 2.10%) growths in comparison to patients with mild ECOPD.
Conclusions: Cellular and bacterial findings in sputum and BAL are related to severity of ECOPD.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2024, Volume 21, Issue 2, Article No: em573

https://doi.org/10.29333/ejgm/14200

Publication date: 01 Mar 2024

Online publication date: 12 Feb 2024

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