Relation between airway cellular and bacterial findings and severity of COPD exacerbations: A multicentric study
Sawsan Bakr Elsawy 1 , Khadiga Salama Mohamed 1 , Eman M Moazen 1 * , Sanaa Fathy Kotb 1 , Amira Mohammad Elsadek Ateya Elsayed 1 , Fatma Gamal Elsayed 1 , Eid Mohammed Mahmoud Mohammed 1 , Ragy Mamdouh Ghaly 2 , Entsar Rafaat Mokhtar 3 , Marwa A Elsaid 3 , Rania Hamid Bahi 4
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1 Department of Chest Diseases, Al-Azhar University, Cairo, EGYPT2 Department of Chest Diseases, Ain Shams University, Cairo, EGYPT3 Department of Clinical Pathology, Al-Azhar University, Cairo, EGYPT4 Department of Chest Diseases, Zagazig University, Zagazig, EGYPT* Corresponding Author


Aim: To evaluate the relationships between sputum and bronchoalveolar lavage (BAL) cellular and bacterial findings and severity of exacerbation of chronic obstructive pulmonary disease (ECOPD).
Patients & methods: A cross-section study was conducted on 307 patients with ECOPD. They underwent sputum and BAL inflammatory cell count and bacterial culture.
Results: Patients with severe ECOPD have significantly higher neutrophils percentage (neut.%), lower lymphocytes percentage (lymph.%), lower eosinophils percentage (eosin.%) and higher neutrophil/lymphocyte ratio (NLR) as compared to patients with mild ECOPD. It was also shown that patients with severe ECOPD had significantly higher BAL neut.%, lower lymph.%, lower eosin.%, and higher NLR as compared to the other two subgroups. Also, patients with severe ECOPD have significantly higher frequency of cases with monomicrobial (71.30% vs. 36.10%) and polymicrobial (21.25% vs. 2.10%) growths in comparison to patients with mild ECOPD.
Conclusions: Cellular and bacterial findings in sputum and BAL are related to severity of ECOPD.


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Article Type: Original Article

ELECTRON J GEN MED, 2024, Volume 21, Issue 2, Article No: em573

Publication date: 01 Mar 2024

Online publication date: 12 Feb 2024

Article Views: 247

Article Downloads: 292

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