PROTECTIVE EFFECTS OF QUERCETIN, A FLAVONOID ANTIOXIDANT, IN ABSOLUTE ETHANOL-INDUCED ACUT GASTRIC ULCER
Ömer Coşkun 1 * , Mehmet Kanter 1, Ferah Armutçu 2, Kurtuluş Çetin 1, Betül Kaybolmaz 1, Ömer Yazgan 1
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1 Karaelmas University, Faculty of Medicine, Department of Medical Histology-Embryology, Zonguldak, Turkey
2 Karaelmas University, Faculty of Medicine, Department of Biochemistry, Zonguldak, Turkey
* Corresponding Author

Abstract

Free radicals have been reported to be responsible for many ailments including gastroduodenal ulcers. Recent studies demonstrated that quercetin (QE) has an antioxidant effects on injuries caused by various toxic agents in different experimental models. In our study, we examined anti-ulcerogen and antioxidant effects of quercetin on ethanol-induced gastric lesions in rats. QE was administered intraperitoneally (i.p.) 50 mg/kg. It was found that pretreatment with QE significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and significantly increased antioxidant enzyme activities. We conclude that QE clearly has antioxidant properties and that the protective effect of QE against ethanol-induced gastric mucosal lesion, at least in part, depends upon the reduction in the lipid peroxidation and an increase in the activity of antioxidant enzymes.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejgm/82201

EUR J GEN MED, 2004 - Volume 1 Issue 3, pp. 37-42

Publication date: 15 Jul 2004

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