Free radicals have been reported to be responsible for many ailments including gastroduodenal
ulcers. Recent studies demonstrated that quercetin (QE) has an antioxidant effects on injuries
caused by various toxic agents in different experimental models. In our study, we examined
anti-ulcerogen and antioxidant effects of quercetin on ethanol-induced gastric lesions in rats.
QE was administered intraperitoneally (i.p.) 50 mg/kg. It was found that pretreatment with
QE significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and
significantly increased antioxidant enzyme activities. We conclude that QE clearly has antioxidant
properties and that the protective effect of QE against ethanol-induced gastric mucosal lesion, at
least in part, depends upon the reduction in the lipid peroxidation and an increase in the activity
of antioxidant enzymes.