Aim: To investigate the preemptive effect of etofenomate on
postoperative pain and emesis in the first 24 hours after elective
Method: Patients were randomly assigned to two groups each
consisting of 60 patients. Group A was received 1g (2 ml) etofenomate
intramuscularly, group B was received 0.9% saline intramuscularly one
hour before surgery. All patients were administered meperidine HCl in
the patient –controlled analgesia (PCA) intravenous mode in order to
treat postoperative pain. Pain intensity was assessed on visual analog
scales (VAS) at four times; 1 hour, 6 hours, 12 hours and 24 hours.
The total meperidine HCl consumptions, VAS scores and antiemetic
requirements were recorded and comparisons among the two groups
Result: The mean total meperidine HCl consumptions within first 6
and 24 hours of the group A were significantly less than the group B.
The VAS scores at 1 and 6 hours in the group A were significantly lower
than that in the group B. There was no significant difference in the
postoperative antiemetic requirement among two groups.
Conclusion: Preemptive use of etofenamate reduces pain intensity
and meperidine HCl requirement, but it doesn’t affect the
antiemetic requirement in elective laparoscopic cholecystectomy.