Nodular liver lesions commonly represent solid tumour metastases. However, haematological neoplasms should also be considered as primary cause. Extramedullary infiltration of multiple myeloma with hepatic invasion at diagnosis is uncommon. We describe an unusual case of a woman presenting with multiple liver lesions initially suggesting disseminated solid tumour disease. She appeared to have widespread plasmablastic myeloma, an aggressive subtype of multiple myeloma, instead.