Aim: We aimed to investigate the levels and relationships of antioxidants,
lipid peroxidation and leptin altogether in marasmic
Method: Thirty marasmic children (age 14.4±10.3 months) and 28 control
subjects were included. Erythrocyte superoxide dismutase (SOD)
and catalase (CAT) activities, glutathione (GSH) level, and serum
malondialdehyde (MDA) and leptin levels were measured.
Result: Malnourished children had significantly lower erythrocyte
SOD activity (1583±417 vs. 3403±1901 U/gHb, respectively,
P<0.001), CAT activity (1139±92 vs. 1663±302 k/gHb, p<0.001), GSH
level (25.9±5.4 vs. 48.1±17.0 μmol/gHb, p<0.001) and leptin levels
(3.6±1.1 vs. 11.8±4.5 ng/mL, respectively, p<0.001), compared with
control subjects. However mean MDA concentration of marasmic children
(11.1±2.5 nmol/mL) was found to be significantly higher than
that of the control subjects (6.6±3.9 nmol/mL) (p<0.001). Significant
negative correlations were detected between CAT and MDA (r=-0.476,
P=0.009), between SOD and MDA (r=-0.534, p=0.004), and GSH and
MDA (r=-0.439, p=0.015) in marasmic children. No significant correlation
was found between leptin and oxidation markers (p>0.05).
Conclusion: Marasmic children had increased lipid peroxidation and
decreased antioxidant enzyme activities and leptin. Lack of associations
between leptin, anthropometric measurements and oxidative
stress may be due to the excessive loss of adipose tissue and related
very low levels of leptin in marasmic children.