OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN BRONCHOALVEOLAR LAVAGE FLUID, PLASMA AND ERYTHROCYTE OF CRITICALLY MIXED ILL WITH RESPIRATORY FAILURE
Sadık Büyükbaş 1, Kürşat Uzun 2 * , Elif Demirkapı 1, Kemal Başaralı 1
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1 Selcuk University, Meram Faculty of Medicine, Department of Biochemistry, Konya, Turkey2 Selcuk University, Meram Faculty of Medicine, Department of Pulmonary Diseases, Konya, Turkey* Corresponding Author

Abstract

Aim: Increased oxidative stress is a significant part of pathogenesis of various lung diseases. In this trial, it is aimed to determine the role of oxidative stress in patients receiving mechanical ventilation for respiratory failure (RF). Methods: The oxidative stress was evaluated by determining plasma, bronchial fluid and erythrocyte levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), ascorbic acid, alpha-tocopherol, uric acid (UA) and nitric oxide (NO) in 25 critically ill patients with RF. Twenty five patients without RF was evaluated as control group. Results: Oxidative stress (MDA, NO) levels of plasma, erythrocyte and BAL fluid in mixed critically ill with respiratory failure were higher than control group. Antioxidant levels of plasma, erythrocyte and BAL fluid in mixed critically ill with respiratory failure were lower than control group. In all parameters, there was no statistically difference as exitus and survivors in critically mixed patients. Conclusion: Oxidative stress was higher in respiratory failure than control group.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2008, Volume 5, Issue 3, 140-146

https://doi.org/10.29333/ejgm/82595

Publication date: 15 Jul 2008

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