Extra nasopharyngeal angiofibroma (ENA) is a term used for fibrous nodules that are located outside the nasopharynx. Location of angiofibromas outside the nasopharynx is rare. In addition, septum is an extremely rare area for involvement. While 11 nasal septum-originated cases have been reported until today in the literature, no septal angiofibromas during pregnancy have been reported yet. We are presenting a nasal septum-originated angiofibroma case in a 26-year old pregnant woman, together with literature data.