Multicentric gliomas are uncommon lesions but a fascinating clinical and scientific issue. Current opinion ranges from rejection of surgical treatment to its recommendation. We report a case of young adult who presented with one episode of generalized tonic clonic seizures and mild weakness of right hand. Imaging findings were suggestive multiple lesions in the left temporo-parietal area. Surgical decompression was performed for the larger lesion and histopathology was suggestive of glioblastoma multiforme. Based on these findings a diagnosis of multifocal glioblasotma was made. Patient was submitted for radiotherapy. In patients with multiple lesions tissue analysis is critical for treatment planning and to determine the prognosis.