Medical Applications of Siderophores
Basavraj Nagoba 1 * , Deepak Vedpathak 2
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1 Maharashtra Institute of Medical Science and Research Medical College, Latur, India
2 Rajarshi Shahu College, Latur, India
* Corresponding Author

Abstract

The literature survey presented in this review shows that the knowledge regarding the structure of various siderophores and the presence of microbial membrane receptors that operates in iron uptake from these iron – siderophore complexes have opened newer avenues for research. Siderophores and their substituted derivatives have a large number of applications in medical sciences. The most important application is selective drug delivery, a Trojan horse strategy, to defeat drug resistant bacteria. The Trojan horse strategy is most promising way to specifically attack multiple antibiotic resistant strains of bacteria associated with life threatening infections. Other major clinical applications include treatment of diseases like haemochromatosis, thalassemia, dialysis encephalopathy, removal of transuranic elements such as aluminium and vanadium and anti-malarial activity.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Review Article

https://doi.org/10.29333/ejgm/82743

EUR J GEN MED, 2011 - Volume 8 Issue 3, pp. 229-235

Publication date: 11 Jul 2011

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Article Downloads: 1187

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