Mechanism of Action of Jatropha Gossypifolia Stem Latex As a Haemostatic Agent
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Taofeeq Oduola 1 * , Ganiyu Oyebola Adeosun 2, Tesleem Aderemi Oduola 3, Godwin Ovie Avwioro 4, Mutiyat Adeyoola Oyeniyi 1
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1 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Hematology, Ile-Ife, Osun State, Nigeria.
2 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Chemical Pathology, Ile-Ife, Osun State, Nigeria.
3 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Medicine, Ile-Ife, Osun State, Nigeria.
4 Obafemi Awolowo University Teaching Hospital Complex, School of Medical Laboratory Sciences, Department of Histopathology, Ile-Ife, Osun State, Nigeria.
* Corresponding Author

Abstract

Aim: Jatropha gossypifolia belongs to the family “Euphorbiacea”. The coagulant activity and the mechanism of action of Jatropha gossypifolia stem latex as a haemostatic agent were investigated. Methods: The mechanism of action was investigated using doubling dilution technique by mixing neat (undiluted) and serial dilutions of the latex with 30% bovine albumin. Results: The results of whole blood clotting time using Lee and White method and bleeding time using Ivy’s method were significantly reduced (P < 0.05) when stem latex was introduced than when the tests were performed without stem latex. This means that the stem latex possesses procoagulant activity. Conclusion: The result of this test showed that precipitation of coagulant factors is the mechanism of action of its haemostatic activity.

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Article Type: Original Article

https://doi.org/10.29333/ejgm/82329

EUR J GEN MED, 2005 - Volume 2 Issue 4, pp. 140-143

Publication date: 15 Oct 2005

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