Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Staphylococcus Aureus
Süleyman Durmaz 1 * , Aslı Kiraz 2, Turkan Toka Özer 1, Duygu Perçin 3
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1 Mevlana University, Faculty of Medicine, Department of Medical Microbiology, Konya, Turkey
2 Canakkale Onsekiz Mart University, Faculty of Medicine, Department of Medical Microbiology, Canakkale, Turkey
3 Erciyes University, Faculty of Medicine, Department of Medical Microbiology, Kayseri, Turkey
* Corresponding Author


Staphylococcus aureus is one of the most frequently isolated pathogens in community and hospital-acquired infections. Macrolide-lincosamide-streptogramin B (MLSB) group antibiotics have frequently been preferred. In this study, it was aimed to determine MLSB group antibiotics resistance phenotypes observed in S. aureus strains. A total of 182 S. aureus strains were included in the study. Methicillin resistance was assessed using the cefoxitin (30μg) disc, MLSB resistance phenotypes were assessed using D zone test with erythromycin (15μg) and clindamycin (2μg) discs according to the Clinical and Laboratory Standards Institute (CLSI) recommendations. Of the strains included in the study, 38 (20.9%) methicillin-resistant S.aureus (MRSA) and 144 (79.1%) methicillin-susceptible S.aureus (MSSA) were identified. MLSB resistance phenotype was found in 65 (35.7%) strains. MLSB resistance was found 84% in MRSA strains and 23% in MSSA strains: There was statistically significant between MRSA and MSSA strains. Constitutional MLSB resistance was found higher in MRSA strains (71%) and however, in MSSA strains was higher inducibleMLSB resistance (16.5%). It is suggested that, using the D test method in routine antibiotic susceptibility testing and determining resistance phenotypes in microbiology laboratories is the right approach and may play an important role in the prevention of treatment failure according to the substantial proportion of inducible resistance MLSB resistance observed.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, 2014 - Volume 11 Issue 4, pp. 217-220

Publication date: 15 Oct 2014

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