Investigation Of Anti-Inflammatory Activity Of Bergamot Oil
Mehmet Karaca 1, Hanefi Özbek 2 * , Aydın Him 3, Mehmet Tütüncü 1, Hasan Altan Akkan 1, Veysel Kaplanoğlu 2
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1 Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Internal Medicine, Van, Turkey2 Yüzüncü Yıl University, Medical Faculty, Department of Pharmacology, Van, Turkey3 Yüzüncü Yıl University, Medical Faculty, Department of Physiology, Van, Turkey* Corresponding Author


Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

EUR J GEN MED, Volume 4, Issue 4, October 2007, 176-179

Publication date: 15 Oct 2007

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