Impact of supplemental vitamin D3 and calcium on hypercholesterolemia
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Ali Sanjari Moghaddam 1, Shahnaz Tofangchiha 2 * , Ebadallah Shiri Malek Abad 3
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1 School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Internal Medicine, AJA University of Medical Sciences, Tehran, Iran
3 Department of Social Medicine, School of Medicine, AJA University of Medical Sciences, Tehran, Iran
* Corresponding Author

Abstract

Aim:
In the present crossover study, we aimed to assess if calcium and vitamin D can help statins for treatment of hypercholesterolemia.

Method:
This crossover study was conducted on 60 participants with newly diagnosed hypercholesterolemia. In first phase of study, all patients were administered one 20-mg tablet of atorvastatin every bedtime for sex weeks. Thereafter, in the second phase, all participants received 400 IU vitamin D3 and 1000 mg calcium in addition to previous regimen. After each phase, Lipid profile was evaluated for all participants.

Results:
60 individuals including 26 men (43.3%) and 34 women (56.7%) participated in this study. There was significant decrease in triglyceride, total cholesterol and LDL after six weeks treatment with atorvastatin. However, HDL showed no significant change. When blood lipid values after statin therapy was compared to the values after treatment with atorvastatin plus supplemental calcium and vitamin D3, none showed statistically significant change. BMI was found to decrease significantly in both phase of treatment, but blood pressure showed no change.

Conclusion:
In summary, we observed that supplemental calcium and vitamin D3 have no significant impact on lipid profile and blood pressure. However, we found that supplemental calcium and vitamin D3 decreased BMI, but more studies are in need to support our results.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

https://doi.org/10.29333/ejgm/85681

ELECTRON J GEN MED, 2018 - Volume 15 Issue 3, Article No: em27

Publication date: 03 Mar 2018

Article Views: 1075

Article Downloads: 702

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