Factors related ART adherence and quality of life in PLHIV: Mediating role of positive self-care management and brain gym
Nursalam 1 * , Tintin Sukartini 1 , Khatijah Lim Abdullah 2 , Misutarno 1 3 , Idyatul Hasanah 4
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1 Faculty of Nursing, Airlangga University, Surabaya, INDONESIA2 Faculty of Medicine, University of Malaya, Kuala Lumpur, MALAYSIA3 Faculty of Nursing and Midwifery, Universitas Nahdlatul Ulama Surabaya, Surabaya, INDONESIA4 STIKES Yarsi Mataram, Mataram, INDONESIA* Corresponding Author


Objectives: To investigate the factors affecting adherence to antiretroviral therapy (ART) and the quality of life in people living with human immunodeficiency virus (HIV), with a focus on evaluating the mediating roles of positive self-care management (PSCM) and brain gym.
Methods: This is a descriptive study with a cross-sectional design. The data collected from June to August 2023. There are 262 respondents selected through convenience sampling. We used various research instruments, including questionnaires, which have undergone validity and reliability testing. The data were analyzed using the SEM-PLS analysis method.
Results: Our data analysis shows that condition factors, physical and social environmental factors, and individual and family factors affect HIV individuals’ PSCM and brain gym combination, ART adherence, and quality of life. Findings show that condition-specific factors indirectly affect antiretroviral drug adherence. This impact is mediated by PSCM and brain gym.
Conclusions: Specific condition variables, namely complexity of the disease, barriers, and stability of conditions indirectly influence ART adherence, mediated through the combined influence of PSCM and brain gym. This finding suggests that to enhance adherence and the quality of life among PLHIV, it is important to adopt an approach that encompasses a range of internal and external individual factors.


This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, Volume 21, Issue 3, June 2024, Article No: em588


Publication date: 08 May 2024

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