Epithelial-Myoepithelial Carcinoma with High Grade Transformation of Nasal Cavity
Fahriye Kılınç 1 * , Münire Durmaz Çağın 1, Erkun Tuncer 1, Duran Efe 1, Süleyman Özen 1
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1 Mevlana University, Konya, Turkey
* Corresponding Author


High grade transformation in epithelial-myoepithelial carcino¬ma is a recently defined entity with only a few cases reported in the literature. We present a 59 years old female patient with a polypoid lesion in nasal cavity, together with clinical com¬plaints as recurrent epistaxis and stuffiness. Histological and immunohistochemical examination of the surgically excised le¬sion revealed a diagnosis of epithelial-myoepithelial carcino¬ma with high grade transformation. Epithelial-myoepithelial carcinoma originates from salivary glands, mainly parotid gland. Other affected sites are submandibular gland and minor sali¬vary glands. Epithelial-myoepithelial carcinoma is characterized by double layered duct-like structures. Greater cytologi¬cal atypia, higher mitotic rate, presence of necrosis and loss of the biphasic duct-like structures are features of high grade transformation. Local recurrence and cervical lymph node me¬tastases are seen with low incidence in classical epithelial-myoepithelial carcinoma, whereas epithelial-myoepithelial carcinoma with high grade transformation has high tendency for lymph node and distant metastases.


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Article Type: Case Report


EUR J GEN MED, 2016 - Volume 13 Issue 1, pp. 72-75

Publication date: 16 Jan 2016

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