Epithelial-Myoepithelial Carcinoma with High Grade Transformation of Nasal Cavity
Fahriye Kılınç 1 * , Münire Durmaz Çağın 1, Erkun Tuncer 1, Duran Efe 1, Süleyman Özen 1
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1 Mevlana University, Konya, Turkey
* Corresponding Author

Abstract

High grade transformation in epithelial-myoepithelial carcino¬ma is a recently defined entity with only a few cases reported in the literature. We present a 59 years old female patient with a polypoid lesion in nasal cavity, together with clinical com¬plaints as recurrent epistaxis and stuffiness. Histological and immunohistochemical examination of the surgically excised le¬sion revealed a diagnosis of epithelial-myoepithelial carcino¬ma with high grade transformation. Epithelial-myoepithelial carcinoma originates from salivary glands, mainly parotid gland. Other affected sites are submandibular gland and minor sali¬vary glands. Epithelial-myoepithelial carcinoma is characterized by double layered duct-like structures. Greater cytologi¬cal atypia, higher mitotic rate, presence of necrosis and loss of the biphasic duct-like structures are features of high grade transformation. Local recurrence and cervical lymph node me¬tastases are seen with low incidence in classical epithelial-myoepithelial carcinoma, whereas epithelial-myoepithelial carcinoma with high grade transformation has high tendency for lymph node and distant metastases.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Case Report

https://doi.org/10.15197/ejgm.01447

EUR J GEN MED, 2016 - Volume 13 Issue 1, pp. 72-75

Publication date: 16 Jan 2016

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