Effect of the mixed herbal medicines extracts on menopausal symptoms: A randomized clinical trial study
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Inessa A. Minenko 1 * , Rumisa R. Berihanova 2, Svetlana A. Shakhmatova 3
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1 I. M. Sechenov First Moscow State Medical University, Moscow, Russia2 Central Clinical Hospital of Civil Aviation, Moscow, Russia3 Sanatoriun “Laba”, Labinsk, Russia* Corresponding Author

Abstract

Background:
Menopause cause many symptoms, which may impair quality of life the women. The study aims to determine the effectiveness of mixed herbal medicinal extracts on menopausal symptoms.

Method:
A randomized, triple-blind, placebo-controlled clinical trial was conducted on 120 peri-menopausal women for 12 weeks. All participants took herbal extracts drops orally daily. They were randomly allocated into four groups: placebo (C), A (250 mg chamomile, 30 mg fennel, 15 mg saffron), B (1000 mg chamomile, 120 mg fennel, 60 mg saffron), and D (500 mg chamomile, 60 mg fennel, 30 mg saffron).They completed a demographic and MRS questionnaire at week 0, 6.12.

Result:
108 participants successfully completed the assessment. No significant differences in demographic variables were seen between the four groups. The median MRS score was significantly reduced in group B from 27.5±3 to 7.5±5. In group D, it was significantly reduced from 29±12 to 22±9.25The effect size in this study was 0.92.

Conclusion:
Study showed significant improvement in menopausal symptoms especially in group B.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2019, Volume 16, Issue 3, Article No: em137

https://doi.org/10.29333/ejgm/109435

Publication date: 16 May 2019

Article Views: 2088

Article Downloads: 1750

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