Disease control and its associated factors in outpatients with rheumatoid arthritis
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Anan S Jarab 1 2 , Walid Al-Qerem 3 , Shrouq R Abu Heshmeh 1 , Karem H Alzoubi 4 5 , Tareq L Mukattash 1 , Amal Akour 6 7 *
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1 Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JORDAN2 College of Pharmacy, Al Ain University, Abu Dhabi, UNITED ARAB EMIRATES3 Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, JORDAN4 Department of Pharmacy Practice and Pharmacotherapeutics, College of Pharmacy, University of Sharjah, Sharjah, UNITED ARAB EMIRATES5 Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, JORDAN6 Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, UNITED ARAB EMIRATES7 Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, JORDAN* Corresponding Author

Abstract

The present study aimed to evaluate disease activity and explore the factors associated with poor disease control among patients with rheumatoid arthritis (RA). This cross-sectional study was conducted at outpatient rheumatology clinics in two teaching hospitals in Jordan. Medication adherence was assessed using the validated five-item compliance questionnaire for rheumatology, and disease activity was assessed using the clinical disease activity Index score. Ordinal regression was performed to explore the factors associated with uncontrolled RA. Most of the participants (n=261) demonstrated moderate to high disease activity (71.2%). Seronegative RA (B=-0.882, CI [-1.584/-0.180], p<0.05) was significantly associated with lower disease activity, while medication non-adherence was significantly associated with poor RA control (B=1.023, CI [0.289-1.756], p<0.01). Future research should explore the factors associated with medication non-adherence. These factors should be targeted in future interventions to improve RA control, particularly in patients who suffer from high disease severity.

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Article Type: Original Article

ELECTRON J GEN MED, 2023, Volume 20, Issue 6, Article No: em532

https://doi.org/10.29333/ejgm/13521

Publication date: 01 Nov 2023

Online publication date: 01 Aug 2023

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