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Abstract
Background: The effects of vaping, or electronic cigarettes (e-cigarettes), on respiratory health are still debatable, even though it is thought to be a safer alternative to traditional cigarettes. Vape use may affect mucociliary function and increase oxidative stress and inflammation. Ascorbic acid has antioxidant and anti-inflammatory properties that can mitigate tissue damage from chemical exposure. This study aims to compare the impact of vape mod use, ascorbic acid supplementation with a vape mod, and non-smokers (control group) on nasal mucociliary clearance (NMC), interleukin-6 (IL-6), oxidative stress, and lung function to provide a clearer picture of the health risks associated with vape use.
Methods: 45 participants were recruited and randomized into 3 groups: conventional vape mod group, ascorbic acid vape mod group, and control group. The measurement of NMC using the saccharin test, obtained lung function (FVC, FEV1, and PEF) via spirometry, and measured IL-6, reactive oxygen species, and SOD3 levels by sandwich ELISA.
Results: The findings showed that a vape mod with ascorbic acid produced a better response than a conventional vape mod, based on NMC, IL-6, oxidative stress markers, and lung function.
Conclusion: Ascorbic acid use may have protective benefits against mucosal damage and inflammation resulting from chemical exposure, while conventional vape use may worsen respiratory health conditions and cause inflammation and oxidative stress.
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Article Type: Original Article
ELECTRON J GEN MED, Volume 23, Issue 5, October 2026, Article No: em753
https://doi.org/10.29333/ejgm/19442
Publication date: 27 Sep 2026
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