CCL2/MCP-1 level in serum of acute pain syndrome patients with wounds sustained in combat
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Dmytro Dmytriiev 1 , Oleksandr Nazarchuk 1 2 , Oleksandr Dobrovanov 3 4 * , Marian Vidiscak 5 6
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1 National Pirogov Memorial Medical University, Vinnytsya, UKRAINE2 Vinnytsya Regional Clinical Hospital Vinnytsya Regional Council, Vinnytsya, UKRAINE3 Slovak Medical University in Bratislava, Bratislava, SLOVAKIA4 A. Getlik Clinic for Children and Adolescents of Slovak Medical University and University Hospital of Medicine, Bratislava, SLOVAKIA5 Comenius University in Bratislava, Faculty of Medicine, Bratislava, SLOVAKIA6 IV. Surgical Clinic of Faculty of Medicine of Comenius university in Bratislava and University Hospital Bratislava, Bratislava, SLOVAKIA* Corresponding Author

Abstract

Background: The aim of our study was to examine the relationship between the inflammatory response and the pain response by determining the level of C-C motif chemokine ligand 2 (CCL2)/mono-cytechemoattractant protein-1 (MCP-1) in the serum of patients with combat injuries in the perioperative period with different methods of analgesia.
Materials and methods: The study involved 24 servicemen with gunshot wounds to extremities of various localizations due to a mine or explosive mechanism. The patients were divided into 2 groups: group 1 (n = 12)–received standard general anesthesia (with intravenous infusion of 0.005% fentanyl, morphine 1%), group 2 (n = 12)–combination of general anesthesia and infiltration anesthesia of the wound with 0.5% bupivacaine.
Results: The plasma CCL2/MCP-1 level in the patients prior surgery averaged 19.15 ± 6.80 pg/ml pg/ml; (p < 0.05). After 12 hours in patients from group 1 there was an increase in the level of CCL2/MCP-1 in the blood plasma (3.1 times), p < 0.05, and 9.5 times 24 hours after surgery. In group 2 there wasn’t an increase in inflammatory markers after 12 hours, but after 24 hours after surgery, plasma CCL2/MCP-1 level significantly increased 3.3 times (p < 0.05). In the preoperative period the pain intensity ranked by the visual analog scale 7.8 scores, in the postoperative period, the degree of pain intensity was quantitatively the lowest in group 2.
Conclusions: MCP-1 biomarker levels may be an indicator of the intensity of the inflammatory process and pain in the perioperative period. The CCL2/MCP-1 level is significantly influenced by the type of anesthesia.

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Article Type: Original Article

ELECTRON J GEN MED, Volume 22, Issue 4, August 2025, Article No: em668

https://doi.org/10.29333/ejgm/16519

Publication date: 01 Jul 2025

Online publication date: 18 Jun 2025

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