Association of IL-10 and IL-6 Gene Polymorphisms with Type 2 Diabetes Mellitus among Egyptian Patients
Mohamed Abdel-Halem Helaly 1 * , El-Sayed Zaki Hatata 1, Megahed Abu-Elmagd 1, Eman Fathi Ibrahem 2, Afaf Alsaid 3, Ibrahim Ahmed Abd El-Aal 4, Ahmad Settin 3
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1 Mansoura University, Diabetes and Endocrinology Unit, Specialized Medical Hospital, Mansoura, Egypt
2 Bany Swef University, Internal Medicine Department,Mansoura, Egypt
3 Paediatric Hospital, Genetics Unit, Mansoura, Egypt
4 Mansoura University, Clinical Pathology Department, Mansoura, Egypt
* Corresponding Author


Recent findings indicate that certain cytokines are capable of interfering with insulin sensitive glucose uptake and induce insulin resistance. To test for the association of IL-10–1082 and IL-6–174 genetic polymorphisms with type 2 diabetes mellitus in Egyptian patients. Participants included 69 cases with type 2 DM (31 males and 38 females) with a median age of 57 years in addition to 98 healthy unrelated controls from the Nile Delta region, Egypt. Compared to controls, cases with type 2 diabetes mellitus showed a highly significant increase in the frequency of IL-10–1082 GG genotype (p<0.001, OR = 11.24); higher frequency of IL-10–1082 G allele (p<0.001, OR = 2.2) with a significantly lower frequency of IL-10–1082 GA genotype (p<0.001, OR = 0.22). On the other hand, the IL-6–174 CC genotype frequency was significantly higher in the diabetic group (p<0.001, OR = 5.41) in contrast to the IL-6–174 GC genotype that showed significantly lower frequency (p=0.005, OR = 0.31) with a non significant differences in either G or C allelic frequencies between diabetic and control groups (p>0.05). Polymorphisms related to IL-10–1082 GG and IL-6–174 CC genotypes may be considered as a risk factor for type 2 diabetes mellitus among Egyptian subjects with a potential impact on family counseling and management.


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Article Type: Original Article

EUR J GEN MED, 2013 - Volume 10 Issue 3, pp. 158-162

Publication date: 09 Jul 2013

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